GLUCOSE CORTEX STEROIDS.

Glucose Cortex Steroids are a class of Cortex Steroids, which are a class of Steroid Hormones. The function of this type of hormone is binding to the Glucose Cortex Receptor, that is present in almost every vertebrate animal cell.
Its name Glucose Cortex Steroid is composed from its role in the regulation of 'glucose' metabolism, synthesis in the Adrenal Cortex, and its steroidal structure.
Glucose Cortex Steroids are part of the feedback mechanism in the immune system which reduces certain aspects of immune function, such as reduction of inflammation. They are therefore used in medicine to treat diseases caused by an 'overactive immune system,' such as allergies, asthma, auto-immune diseases, and sepsis.
Glucose Cortex Steroids affect cells by binding to the Glucose Cortex Receptor. The receptor is an important representative of Neuro-Endocrine Integration, functioning as a major component of endocrine influence -specifically the stress response- upon the brain. The receptor is implicated in both short and long term adaptations in response to stresses.
Glucose Cortex Steroids are distinguished from Mineral Cortex Steroids and Sex Steroids by their specific Receptors, Target Cells, and effects.
Glucose Cortex Steroids have many diverse effects, including potentially harmful side effects.
Since they interfere with some of the abnormal mechanisms in cancer cells, Glucose Cortex Steroids are used in high doses to treat cancer. This treatment includes: inhibitory effects on lymphocyte proliferation as in  the treatment of lymphomas and leukemia; and the mitigation of side effects of anticancer drugs.
Cortisol or Hydrocortisone, a Steroid Hormone, in the Glucose Cortex Steroid class, is produced in humans by the middle zone of the adrenal cortex, sitting directly beneath the most superficial layer of the adrenal cortex. The adrenal cortex, situated along the perimeter of the adrenal gland, mediates the stress response through the production of other secrete distinct hormones.
The adrenal cortex comprises 3 main layers or zones:
- The outermost layer produce the main Mineral Cortex Steroid (aldosterone). It plays a central role in the regulation of the plasma sodium (Na), the extra cellular potassium (K), and arterial blood pressure.
- The middle layer produce Glucose Corticoids, mainly the Cortisol Hormone in humans, which regulates metabolism of the 'glucose,' specially in times of stress (fight-or flight response). Cells are organized into bundles.
Cortisol secretion is stimulated by the Adrenal Corticotropic Hormone, a Poly Peptide tropic hormone produced and secreted by the anterior Pituitary Gland. It is an important component of the Hypothalamic-Pituitary-Adrenal axis and is often produced in response to biological stress along with its precursor Corticotropin-releasing Hormone from the Hypothalamus. It affects the production and release of Cortisol by the cortex of the adrenal gland.
Cortisol is the most importasnt human Glucose Corticoid secreted at a basal level in humans under normal conditions.  It regulates or supports a variety of important cardiovascular, metabolic, immunologic, and homeostatic functions. Its job include mobilization of fats, proteins, and carbohydrates, and it does not increase under starvation conditions. Additionally, it enhances the activity of other hormones.
- The inner most cortical layer produces Androgens, mainly De-Hydro-Epi-Andro-Sterone, De-Hydro-Epi-Andro-Sterone sulfate, and Andro-Stene-Dione, precursor to Testo-Sterone in humans.
De-Hydro-Epi-Andro-Sterone is an endo-genous steroid hormone, and the most abundant circulating steroid hormone in humans that originate from within as well as in any organism, tissue, or cell.
In humans the hormone is secreted in the adrenal glands, the gonads, and the brain, where it functions predominantly as a metabolic intermediate in the biosynthesis of the Androgen and Estrogen sex steroids. It also has a variety of potential biological effects in its own right, binding to an array of nuclear and cell surface receptors, and acting as a Neuro-Steroid.
Viral elements travel time as endo-genous sequences derived from viruses ancestrally inserted into genomes of germ cells. These sequences persists in the germ-line as host alleles a short form of Allelo-Morph meaning 'other form.'
The presence of DHEA sulfate hormone is used to rule out ovarian or testicular cancer. The levels of this hormone decline as a person ages as the inner layer diminishes in size.
Andro-Stene-Dione hormone sometimes referred to as 'Andro' was banned as a prescription hormone by the International Olympic Committee in 1997.
Glucose Cortex Steroids have multiple effects on fetal development. An important example is their role in promoting maturation of the lung and production of the surfactant, compounds that lower the surface tension, necessary for extra uterine lung function. In addition, Glucose Cortex Steroids are necessary for normal brain development, by initiating terminal maturation, remodeling axons and dendrites, and affecting cell survival and in the hippo campus development.
Glucose Cortex Steroids act on the hippo-campus, amygdala, and frontal lobes. Along with adrenaline, enhance the formation of flush bulb memories of events associated with strong emotions, both positive and negative. A flush bulb memory is the existence of a special biological memory mechanism which is highly detailed, and exceptionally vivid, of the moment and circumstances that were triggered by an event that exceeded critical levels of surprise and consequentiality. This memory creates a permanent record of the details and circumstances surrounding the experience.
The effects that Glucose Cortex Steroids have on memory go specifically to the area of the hippo campus formation in which prolonged stress produces destruction of the neurons in this area and connected to memory performance. Long-term exposure to Glucose-Cortex Steroids medications, such as asthma and anti-inflammatory medication, creates deficits in memory and attention both during at, to a lesser extent, after treatment, a condition known as 'steroid dementia.'
Glucose Cortex Steroids act centrally, as well as peripherally, to assist in the normalization of extra cellular fluid volume by regulating the human body's action to Atrial Natri-Uretic peptide.
The Atrial Natri-Uretic is a 28-amino acid peptide with a 17-amino acid ring in the middle of the molecule, a powerful vaso-dilatador, and a protein (poly-peptide) hormone secreted by muscle cells in the upper chambers (atria) of the heart (atrial myocytes) in response to high blood volume. The peptide is closely related to Brain Natri-Uretic peptide and C-type Natri-Uretic peptide, which all share a similar amino acid ring structure.
It is involved in the homeostatic control of body reducing the water, sodium, potassium, and fat (adipose tissue) loads on the circulatory system, thereby reducing blood pressure.
The Atrial Natri-Uretic peptide has exactly the opposite function of the Aldo Sterone secreted by the most superficial layer of the Adrenal Cortex in regard to its effect on sodium in the kidney -that is, Aldo Sterone stimulates sodium retention and Atrial Natri-Uretic peptide generates sodium loss.
Synthetic Glucose Cortex Steroids have been created in a very great variety for therapeutic use, some far more potent than Cortisol. They differ in both pharmaco-kinetics (absorption factor, half-life, volume of distribution, clearance) and pharmaco-dynamics (for example the capacity of mineral- cortex-steroid activity: water and sodium retention; renal physiology).
Because they permeate the intestines easily, they are administered primarily by mouth, but also by other methods, such as topically on skin. More than 90% of them bind different plasma proteins, though with a 'different binding' specificity.
Endo-Genous Glucose Cortex Steroids and some synthetic cortex-steroids have high affinity to the protein Trans-Cortin (also called Cortex Steroid Binding Globulin), whereas all of them bind albumin.
In the liver, they quickly metabolize by conjugation with a Sulfate or Glucose-Uric acid, and are secreted in the urine.